Epithelial-mesenchymal transition in tumor development

The Research Group on Epithelial-mesenchymal transition in tumor development is a research group of Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) affiliated to Universitat Pompeu Fabra (UPF) led by Dr. Antonio García de Herreros. The group focuses on the study of mechanisms controlling E-cadherin function and its relevance in neoplasias.

The main research lines are:

  • Analysis of gene expression control by E-cadherin and associated proteins: role in Wnt factor-activated signal transduction pathway. 
  • Characterization of the mechanisms controlling E-cadherin gene expression in tumor cells and their implications in tumor development.
  • Molecular mechanisms promoting a pro-metastatic tumor stroma.
  • Ubiquitin ligases involved in Snail regulation during EMT and cancer.